January 18, 2022 0 Comments

If you are looking to stay alert and focused while drinking alcohol, then there is a way for you to do so. The best thing is that you can mix the two together! One of my favorite drinks is Irish coffee. This drink consists of coffee with milk or cream, whiskey or brandy (or both), sugar, and whipped cream on top. It tastes great but has a lot more caffeine than I would like to take in before bedtime. So what I do is add some Modafinil powder into the cup prior to adding any other ingredients. After all, it’s just one extra scoop of powder! This will keep me up through the night if need be without making me feel jittery from too much caffeine intake

What Is Modafinil?

mixing modafinil

Modafinil is a medicine that is used to treat sleepiness due to narcolepsy, shift work disorder, or obstructive sleep apnea. While it has been shown to have off-label usage as a purported cognitive enhancer for enhancing wakefulness in animal and human studies, the evidence for its efficacy for this purpose is not conclusive

Modafinil is generally well-tolerated, although it may cause headaches, sleeplessness, and nausea. People with a history of psychosis or those who are sensitive to it have a higher risk of having serious adverse effects that include an allergic reaction known as anaphylaxis and a rare but severe skin condition called Stevens-Johnson syndrome. It’s unclear whether Modafinil is safe to use during pregnancy. Those with kidney or liver disease may need to decrease the amount of medicine used. It’s not advised in people with arrhythmia, high blood pressure, or left ventricular hypertrophy. Modafinil works by influencing dopamine and modulating areas of the brain associated with sleep pattern generation.

How does Modafinil work?

stimulant drug

Modafinil promotes wakefulness, and it appears to do this by altering the natural chemicals in your brain. It’s supposed to work on a part of the brain called the hypothalamus. The exact way it works isn’t clear though

Studies have shown that Modafinil stimulates multiple areas in the brain including the anterior cingulate cortex (ACC), which is involved with attention switching; the striatum, which plays an important role in goal-directed behavior like planning ahead; and parts of the thalamus responsible for maintaining alertness.   Another study found similar results, showing increased activation levels of these same regions when patients were given Modafinil vs placebo. When people took Modafinil they reported feeling more alert, focused, and energetic.

Modafinil was approved by the FDA in 1998 to be used as a treatment for narcolepsy. It’s also been shown effective at treating sleepiness due to shift work disorder or obstructive sleep apnea. Modafinil works differently than most other stimulants available today like Adderall (amphetamine) and Ritalin (methylphenidate). The effects of these drugs are considered “selective” meaning they mainly affect one area of the brain rather than multiple areas. Modafinil on the other hand is thought to have an overall effect where it increases neuronal activity across many different regions simultaneously which gives rise to its energizing properties known as eugeroics  or ” wakefulness-promoting agents “

How does alcohol work?

modafinil alcohol interactions

Alcohol is a depressant, which means it slows down the brain and body. Alcohol can also have effects on mood by increasing positive feelings and decreasing negative feelings. It can also affect judgment and decision-making abilities. When someone drinks alcohol, it is absorbed into the bloodstream and goes to the brain. There, it blocks some of the messages that are sent between nerve cells. This slows down communication in the brain and affects a person’s thinking, movement, vision, hearing, and coordination

Alcohol interferes with the transmission of glutamate, which is an important chemical messenger involved in learning and memory. Alcohol also decreases levels of serotonin, which helps regulate mood. As a result, people who drink alcohol may feel happy or relaxed in the short term but could experience problems with their memory and emotional stability in the long-term

Mixing Modafinil and alcohol

drug abuse

Provigil is a pharmaceutical that is meant to help people with sleep problems stay awake longer. Narcolepsy, idiopathic hypersomnia, obstructive sleep apnea, excessive daytime drowsiness, and shift-work disorder are examples of such conditions.

Mixing Provigil with alcohol has both expected and unexpected effects. Mixing Modafinil and alcohol can cause a variety of problems, including blackouts and increased tolerance to alcohol. A person who abuses Modafinil can combine it with alcohol. Although more study is required to determine the consequences of mixing the two chemicals.

Modafinil and alcohol have opposing effects on the brain’s chemistry. The neurotransmitter GABA activity rises while glutamate activity decreases in a person who is taking alcoholic beverages. The medicine is called a GABA antagonist because it reduces the production of GABA and boosts glutamate synthesis.

The total effect of combining these substances is a tug of war between opposing neurotransmitters. While one helps in stimulating activity in a particular direction, alcohol addiction reduces brain activity in the opposite direction. The effects can be unpredictable on the health of an individual.

Risks of mixing Modafinil and alcohol

dietary supplements

Most psychoactive substances fall somewhere on a spectrum between stimulant and depressant. The drug can be found on the stimulant side of the spectrum, while alcohol is on the depressant side. Both drugs have different withdrawal symptoms and negative impacts.

Here are the side effects of mixing Modafinil and alcohol:

  • Dehydration is one of the most serious consequences. It reduces water in the body: combining Modafinil and alcohol will result in a lowering of water levels. This happens as a result of the human body’s requirement for water, which aids in metabolism and breakdown. It also promotes renal loss via hydration, allowing molecules to
  • It can have a detrimental effect on the liver: Almost all substances that enter the human body are metabolized by the liver. The liver is tasked with converting chemicals with active and inactive metabolites into excretion products for the kidneys or bowels.

The liver’s CYP450 isoenzymes are a group of enzymes that carry out specialized functions to achieve what is referred to as the “CYP450 isoenzymes.” A single or more of these enzymes metabolize each substance. Some enzymes are known as CYP3A4 break down the drug, whereas alcohol is broken down by certain

Although everyone may not experience the same symptoms of withdrawal, mixing both might lead to addiction as people develop higher tolerance.

Why Mix Modafinil and alcohol?

taking modafinil

Despite the fact that Modafinil and alcohol have radically different purposes, they are sometimes combined.

The following are some of the most common situations in which alcohol and Modafinil combine.

1. To boost energy before an event

Have you ever left a long day at work exhausted and ready for bed only to discover that you have prior plans to attend a wedding or party? Most of us have, and it takes a lot of willpower to get ready in order to go out for the night.

Modafinil offers a unique benefit in these situations.

Modafinil stimulates wakefulness in the brain as a eugeroic. Although it isn’t a substitute for sleep, it may delay it by several hours. This lets individuals to stay awake and attend events they don’t want to miss or can’t afford to miss because of social obligations with friends and family.

In many cases, alcohol is supplied at these events, which means that the alcohol and Modafinil will combine within the body.

2. To stay up all night

Some people even use Modafinil at a party to make them feel more awake during the night, despite the fact that they are already out.

Music festivals and clubs have started to adopt this style. It’s been growing in popularity at nightclubs, especially those that operate all night long until early morning.

This is likely to produce an interaction with alcohol and Modafinil, and in some circumstances, it may lead to the mixing of Modafinil with other substances or illegal drugs.

3. Unintentionally by having drinks after a day on Modafinil

Modafinil and alcohol are also sometimes mixed unintentionally.

Many people use Modafinil to complete a tough project or on a daily basis to treat conditions like narcolepsy or ADHD. Others utilize it to improve productivity and alertness in general.

You could go out for a few drinks with some pals or colleagues after work.

Modafinil’s long half-life ensures that it will be in your body for much of the day and into the early hours of the night. Even though you may not have intended to combine them, alcohol and Modafinil are very likely to combine in the body because of their extended half-lives.

How to reduce side effects of Modafinil and alcohol

excessive daytime sleepiness

It’s been abundantly clear throughout this guide that we don’t recommend combining Modafinil and alcohol, but if the two were to combine, there are a few things you can do to minimize the likelihood of adverse effects.

1. Lower the dose of each

excessive daytime sleepiness

The amount taken of each of these medicines will be the most significant factor in whether or not there will be a negative response.

If you’re going to combine the pills, take a smaller dose than usual to avoid problems. This allows the liver time to focus on what it needs to do and lowers the risk of becoming dehydrated.

Additionally, many users report that when these chemicals are combined, they become drunk much more quickly. This is most likely due to the liver’s incapability of safely processing them.

2. Take with food

alcohol abuse

When individuals take Modafinil with alcohol, they may frequently have an empty stomach. Many of the poor outcomes stated on Reddit forums such as r/Modafinil suggest that someone had taken one or both substances without eating beforehand.

This is a typical side effect of Modafinil, which is why it’s important to avoid snacking during the day.

If you don’t eat all day, then start drinking alcohol on an empty stomach, you’re going to get drunk quickly and have a terrible time as a result of nausea and vomiting.

A healthy meal before or after the test helps to delay both chemicals’ absorption, giving the body the nutrients it needs to deal with the strain on the liver and brain caused by these compounds.

3. Drink plenty of water

alcohol abuse

Both alcohol and Modafinil cause the body to become dehydrated. If left unchecked for long, this can lead to a serious condition.

The easiest method to prevent this is to drink a lot of water while taking Modafinil and alcohol.

Many people avoid water while taking Modafinil or alcohol since frequent urination is required. This is very stupid because the body needs to expel extra amounts of fluid for a reason. If no water is consumed, the kidneys will be unable to eliminate the chemicals from the body, resulting in accumulation and potentially much more serious outcomes.

Many people are aware that the skin is susceptible to breakouts, particularly in hot and humid weather. The body’s natural tendency is to eliminate chemicals via the kidneys before pushing it out of sweat glands in the skin. This might lead to a variety of unpleasant skin problems, including psoriasis and eczema.

4. Don’t mix them

drug interactions

Modafinil may be taken without worrying about causing any negative effects on the body when used occasionally; however, long-term use is certain to have an impact.

If you combine Modafinil with alcohol, it’s critical that you don’t do it every day or even every few days.

Excess strain on the liver over long stretches of time can induce problems including high cholesterol, hyperlipidemia, heart disease, and diabetes.


Can you drink alcohol while on Modafinil?

Yes, but it’s not recommended because the liver doesn’t have time to metabolize both chemicals. The result is you will get drunk very quickly and start feeling nauseous or even vomit in some cases.

What happens when you mix alcohol with Modafinil?

When these two compounds are combined, they can be potentially fatal on their own. The combination of the two only amplifies these effects and can cause serious issues.

How long to wait between alcohol and Modafinil?

You shouldn’t drink immediately after taking either drug, but you should take it before bedtime. This allows the body time to burn off any excess amounts in your system while you sleep. Having a few shots of whiskey before bed is a great way to relax and feel better the next day.

Before you take it, make sure that you’re not going out later in the evening or are planning on drinking alcohol. If so, avoid taking Modafinil until after your night of partying if at all possible. This helps to ensure that neither substance will have an overpowering effect on your body.


The combination of alcohol and modafinil can have serious consequences for your health if not taken properly. It’s important to be aware of the risks before taking either drug and to drink plenty of water while on them. Moderation is key when it comes to both substances, so don’t mix them every day! If you’re going out drinking, avoid taking modafinil during the day. You’ll thank yourself in the morning.


  1. https://medlineplus.gov/druginfo/meds/a602016.html
  2. https://www.medicinenet.com/modafinil/article.htm#is_modafinil_available_as_a_generic_drug
  3. https://pubmed.ncbi.nlm.nih.gov/16389357/
  4. https://www.colgate.edu/about/campus-services-and-resources/parent-alcohol-handbook/how-alcohol-works-body#:~:text=Alcohol%20is%20a%20drug%20that,process%20cannot%20be%20sped%20up.
  5. https://pubmed.ncbi.nlm.nih.gov/15058617/

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